Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues
- Ludovici, DW
- De Corte, BL
- Kukla, MJ
- Ye, H
- Ho, CY
- Lichtenstein, MA
- Kavash, RW
- Andries, K
- de Béthune, MP
- Azijn, H
- Pauwels, R
- Lewi, PJ
- Heeres, J
- Koymans, LM
- de Jonge, MR
- Van Aken, KJ
- Daeyaert, FF
- Das, Kalyan
- Arnold, E
- Janssen, PA
Publication date
September 2001
DOI Publisher
Elsevier BV Journal
Bioorganic & Medicinal Chemistry LettersAbstract
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.status: publishe
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