Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues
- Ludovici, DW
- Kavash, RW
- Kukla, MJ
- Ho, CY
- Ye, H
- De Corte, BL
- Andries, K
- de Béthune, MP
- Azijn, H
- Pauwels, R
- Moereels, HE
- Heeres, J
- Koymans, LM
- de Jonge, MR
- Van Aken, KJ
- Daeyaert, FF
- Lewi, PJ
- Das, Kalyan
- Arnold, E
- Janssen, PA
Publication date
September 2001
DOI Publisher
Elsevier BV Journal
Bioorganic & Medicinal Chemistry LettersAbstract
A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.status: publishe
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