A Case of Hypertrophic Gastropathy and Early Gastric Cancer Associated with Pachydermoperiostosis

Pachydermoperiostosis is a rare hereditary syndrome characterized by finger clubbing, periosteal new bone formation of tubular bones, and hypertrophic skin changes (pachydermia). This syndrome is known to be associated with a variety of diseases such as cranial suture defect, female escuchen, bone marrow failure and autonomic nervous system symptoms such as facial flushing and hyperhidrosis. There are just a few reports documenting gastric ulcer, hypertrophic gastropathy and Crohn' s disease as associated diseases. A case is herein reported of Pachydermoperiostosis accompanied by hypertrophic gastropathy and early gastric cancer. (Korean J Gastrointest Endosc 2000;20:53 57)ope