Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity
- Crunelli, Vincenzo
- Lőrincz, Magor,
- Connelly, William,
- David, Francois
- Hughes, Stuart,
- Lambert, Régis,
- Leresche, Nathalie
- Errington, Adam,
DOIAbstract
International audienceDuring inattentive wakefulness and non-rapid eye movement (NREM) sleep, the neocortex and thalamus cooperatively engage in rhythmic activities that are exquisitely reflected in the electroencephalogram as distinctive rhythms spanning a range of frequencies from <1 Hz slow waves to 13 Hz alpha waves. In the thalamus, these diverse activities emerge through the interaction of cell-intrinsic mechanisms and local and long-range synaptic inputs. One crucial feature, however, unifies thalamic oscillations of different frequencies: repetitive burst firing driven by voltage-dependent Ca2+ spikes. Recent evidence reveals that thalamic Ca2+ spikes are inextricably linked to global somatodendritic Ca2+ transients and are essentia...
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