This article examines the meaningfulness of lexical-semantic relationships. Polysemic lexemes were studied in the synonymy seme and synonyms of sememe which are derived from the meaning of grammar and polysememic lexemes. Synonymic sememes and synonyms are different from lexical synonyms. The grammatical synonyms, context synonyms, complete synonyms, the spiritual synonyms, methodological synonyms, as well as the grammar and lexical units within polysememic lexemes have been studied. There are examples of meaningful words and meaningful additions to grammatical synonyms. Lexical synonyms and affixes synonyms are derived from linguistic units. Syntactic synonyms have been studied in terms of the combination of words, fixed connections and ph...