Anti-cancer drug development typically utilizes high-throughput screening with two-dimensional (2D) cell culture. However, 2D culture induces cellular characteristics different from tumors in vivo, resulting in inefficient drug development. Here, we report an innovative high-throughput screening system using nanoimprinting 3D culture to simulate in vivo conditions, thereby facilitating efficient drug development. We demonstrated that cell line-based nanoimprinting 3D screening can more efficiently select drugs that effectively inhibit cancer growth in vivo as compared to 2D culture. Metabolic responses after treatment were assessed using positron emission tomography (PET) probes, and revealed similar characteristics between the 3D spheroids...
This paper presents a new 3D culture microtechnology for high throughput production of tumor spheroi...
<div><p>3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cel...
Cancer cells have routinely been cultured in 2-dimensions (2D) on a plastic surface. This technique,...
Anti-cancer drug development typically utilizes high-throughput screening with two-dimensional (2D) ...
Two-dimensional (2D) cell cultures are essential for drug development and tumor research. However, t...
Traditional high-throughput drug screening in oncology routinely relies on two-dimensional (2D) cell...
<div><p>The traditional method for studying cancer <i>in vitro</i> is to grow immortalized cancer ce...
Innovative drug screening platforms should improve the discovery of novel and personalized cancer tr...
The traditional method for studying cancer in vitro is to grow immortalized cancer cells in two-dime...
Innovative drug screening platforms should improve the discovery of novel and personalized cancer tr...
Over the past few years, establishment and adaptation of cell-based assays for drug development and ...
3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cell cultur...
Tumors develop within complex cell-to-cell interactions, with accessory cells playing a relevant rol...
This paper presents a new 3D culture microtechnology for high throughput production of tumor spheroi...
Tumors develop within complex cell-to-cell interactions, with accessory cells playing a relevant rol...
This paper presents a new 3D culture microtechnology for high throughput production of tumor spheroi...
<div><p>3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cel...
Cancer cells have routinely been cultured in 2-dimensions (2D) on a plastic surface. This technique,...
Anti-cancer drug development typically utilizes high-throughput screening with two-dimensional (2D) ...
Two-dimensional (2D) cell cultures are essential for drug development and tumor research. However, t...
Traditional high-throughput drug screening in oncology routinely relies on two-dimensional (2D) cell...
<div><p>The traditional method for studying cancer <i>in vitro</i> is to grow immortalized cancer ce...
Innovative drug screening platforms should improve the discovery of novel and personalized cancer tr...
The traditional method for studying cancer in vitro is to grow immortalized cancer cells in two-dime...
Innovative drug screening platforms should improve the discovery of novel and personalized cancer tr...
Over the past few years, establishment and adaptation of cell-based assays for drug development and ...
3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cell cultur...
Tumors develop within complex cell-to-cell interactions, with accessory cells playing a relevant rol...
This paper presents a new 3D culture microtechnology for high throughput production of tumor spheroi...
Tumors develop within complex cell-to-cell interactions, with accessory cells playing a relevant rol...
This paper presents a new 3D culture microtechnology for high throughput production of tumor spheroi...
<div><p>3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cel...
Cancer cells have routinely been cultured in 2-dimensions (2D) on a plastic surface. This technique,...