High attrition of new oncology drug candidates in clinical trials is partially caused by the poor predictive capacity of artificial monolayer cell culture assays early in drug discovery. Monolayer assays do not take the natural three-dimensional (3D) microenvironment of cells into account. As a result, false positive compounds often enter clinical trials, leading to high dropout rates and a waste of time and money. Over the past 2 decades, tissue engineers and cell biologists have developed a broad range of 3D in vitro culturing tools that better represent in vivo cell biology. These tools preserve the 3D architecture of cells and can be used to predict toxicity of and resistance against antitumor agents. Recent progress in tissue engineeri...
3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cell cultur...
BACKGROUND:Three-dimensional (3D) in-vitro cultures are recognized for recapitulating the physiologi...
<div><p>The traditional method for studying cancer <i>in vitro</i> is to grow immortalized cancer ce...
Today, innovative three-dimensional (3D) cell culture models have been proposed as viable and biomim...
Over the past few years, establishment and adaptation of cell-based assays for drug development and ...
Objective. This study was conducted to determine the effectiveness of the anti-cancer drug treatment...
Three-dimensional (3D) cultures are becoming increasingly popular due to their ability to mimic tiss...
In cancer drug discovery, 3D cell culture is a segue between monolayer cell culture and animal testi...
<div><p>3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cel...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
Background: Three-dimensional (3D) in-vitro cultures are recognized for recapitulating the physiolog...
3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cell cultur...
BACKGROUND:Three-dimensional (3D) in-vitro cultures are recognized for recapitulating the physiologi...
<div><p>The traditional method for studying cancer <i>in vitro</i> is to grow immortalized cancer ce...
Today, innovative three-dimensional (3D) cell culture models have been proposed as viable and biomim...
Over the past few years, establishment and adaptation of cell-based assays for drug development and ...
Objective. This study was conducted to determine the effectiveness of the anti-cancer drug treatment...
Three-dimensional (3D) cultures are becoming increasingly popular due to their ability to mimic tiss...
In cancer drug discovery, 3D cell culture is a segue between monolayer cell culture and animal testi...
<div><p>3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cel...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
International audienceCancer is a multifactorial disease that is responsible for 10 million deaths p...
Background: Three-dimensional (3D) in-vitro cultures are recognized for recapitulating the physiolog...
3-dimensional (3D) culture models have the potential to bridge the gap between monolayer cell cultur...
BACKGROUND:Three-dimensional (3D) in-vitro cultures are recognized for recapitulating the physiologi...
<div><p>The traditional method for studying cancer <i>in vitro</i> is to grow immortalized cancer ce...