Add to ORKGThe aim of this project was to explore ways of using biochemical screening to improve the prenatal detection rate for Down's syndrome and other chromosome abnormalities over that being achieved using maternal age alone. It is well established that the risk of a pregnancy being affected by Down's syndrome or one of the other autosomal trisomies increases with advancing maternal age, and since the early 1970s this has been the criterion used to select women for diagnostic fetal chromosome analysis. However, the majority of affected pregnancies (70%) are born to women under 35 years of age and the uptake of diagnostic testing amongst women aged 35 years and over has been relatively low (<40%) leading to only around 12% of the affected pregnanc...
Background: Down’s syndrome (DS), one of the commonest fetal aneuploidy, is associated with mental r...
Objective: Fetal cells and circulating cellfree fetal DNA increases in the maternal circulation in ...
BACKGROUND: Prenatal screening for Down Syndrome (DS) would benefit from an increased number of biom...
Background: Down syndrome originally known as Mongoloid’s idiocy is the most common autosomal disord...
The feto-placental unit synthesises a variety of proteins and hormones which are secreted into the m...
Down Syndrome (DS), also called trisomy 21, is the most common non- lethal fetal aneuploidy that aff...
SummaryObjectiveTo assess the sensitivity of a first-trimester combined screening test for fetal chr...
Prenatal diagnosis still depends on invasive methods using cells contained in the amniotic fluid or ...
Maternal serum triple screen is used to identify women less than 35 years of age who are at an incre...
Background\ud \ud Down's syndrome occurs when a person has three copies of chromosome 21, or the spe...
BACKGROUND: Down's syndrome occurs when a person has three, rather than two copies of chromosome 21;...
Introduction Down syndrome (DS) is the most common single genetic cause of human moderate mental re...
BACKGROUND: Down's syndrome occurs when a person has three, rather than two copies of chromosome 21;...
Chromosomal abnormalities includes 1) abnormalities in number of chromosomes which are known as aneu...
In the period of March 1991 to December 1996, a total of 14,365 sera from pregnant women were invest...
Background: Down’s syndrome (DS), one of the commonest fetal aneuploidy, is associated with mental r...
Objective: Fetal cells and circulating cellfree fetal DNA increases in the maternal circulation in ...
BACKGROUND: Prenatal screening for Down Syndrome (DS) would benefit from an increased number of biom...
Background: Down syndrome originally known as Mongoloid’s idiocy is the most common autosomal disord...
The feto-placental unit synthesises a variety of proteins and hormones which are secreted into the m...
Down Syndrome (DS), also called trisomy 21, is the most common non- lethal fetal aneuploidy that aff...
SummaryObjectiveTo assess the sensitivity of a first-trimester combined screening test for fetal chr...
Prenatal diagnosis still depends on invasive methods using cells contained in the amniotic fluid or ...
Maternal serum triple screen is used to identify women less than 35 years of age who are at an incre...
Background\ud \ud Down's syndrome occurs when a person has three copies of chromosome 21, or the spe...
BACKGROUND: Down's syndrome occurs when a person has three, rather than two copies of chromosome 21;...
Introduction Down syndrome (DS) is the most common single genetic cause of human moderate mental re...
BACKGROUND: Down's syndrome occurs when a person has three, rather than two copies of chromosome 21;...
Chromosomal abnormalities includes 1) abnormalities in number of chromosomes which are known as aneu...
In the period of March 1991 to December 1996, a total of 14,365 sera from pregnant women were invest...
Background: Down’s syndrome (DS), one of the commonest fetal aneuploidy, is associated with mental r...
Objective: Fetal cells and circulating cellfree fetal DNA increases in the maternal circulation in ...
BACKGROUND: Prenatal screening for Down Syndrome (DS) would benefit from an increased number of biom...