MODULATING MULTIPLE DRUG RESISTANCE VIA CO-DELIVERY OF NANOPARTICLE

When various mechanisms in cancer causing cells show resistance towards one or many chemotherapeutics, it hinders the efficacy of chemotherapy. This is referred as multidrug resistance. There are several factors that contribute in MDR. This research specifically focuses on modulate resistance towards multiple drugs by co-delivery of the nanoparticle. This research review has highlighted several delivery systems of nanodrug for overcoming the mechanism followed by MDR. This is done by exploiting, evading or neutralizing the pumps of drug efflux. The research essay has specifically discussed five different system categories. These categories are Mdr-1 and survivin-targeting, Docetaxel and siRNA, Paclitaxel and curcumin, Doxorubicin and paclitaxel and Doxorubicin and PSC 833. Based on the overall discussion, a brief summary is provided. Keywords: Drug resistance, nanomedicine, co-delivery, drug delivery