FORMULATION AND EVALUATION ORAL DISPERSIBLE TABLET OF CINNARIZINE

Oral Dispersible tablets (ODTs) constitute an innovative dosage form, which overcomes the problem of swallowing and provides a quick onset of action. The aim of the proposed work is to formulate fast dissolving tablets of Cinnarizine for rapid dissolution of drug and absorption, which may produce rapid onset of action in the treatment of motion sickness. For this purpose the tablets of Cinnarizine were prepared by Effervescent method, Super disintegrants addition method and Sublimation method. Cinnarizine is an Antihistamines drug has been used for the treatment of motion sickness. Cinnarizine is poorly soluble in water making it a potent candidate fast-dissolving drug delivery system. Key word: ODT, Cinnarizine, Granules, Superdisintegrants