“IN-VITRO EVALUATION OF IMMUNOMODULATORY EFFECT OF POLYHERBAL COMPOUND - BHARANGYADIâ€.

Bharangyadi compound is a polyherbal drug use in Ayurveda system of medicine for the management of allergic disoders such as allergic rhinitis, allergic asthma etc. The present study was carried out to evaluate the immunomodulatory activity of ethanolic extract of polyherbal compound “Bharangyadi†on swiss albino mice. Cyclophosphamide induced immunosuppression model was used to assess the activity of drug. Cyclophosphamide was given in the dose of 30mg/kg body weight through i.p route. 500mg/kg body weight of Bharangyadi polyherbal drug was given through oral route. The extent of protection against immunosuppression caused by Cyclophosphsmide was evaluated after 14 days of drug administration, by estimating hematological parameter and neutrophil adhesion test.Ethanolic extracts of Bharangyadi Compound showed pronounced immunoprotective activity by increasing the depleted levels of total WBC count and RBC, % Hb, and % neutrophils adhesion.The extract was found to be an effective immunomodulatory agent. Keywords: Bharangyadi Compound, ethanolic extract, Immunomodulatory activity, Cyclophosphamide.  Â