OPTIMASI FORMULA FDT NATRIUM DIKLOFENAK DENGAN KOMBINASI SUPERDISINTEGRANT PRIMOJEL®, PRIMELLOSE®DANKOMPONEN EFFERVESCENT DENGANMETODE SIMPLEX LATTICE DESIGN

Diclofenac sodium is a non steroidal anti-inflamation drug that generally has been used as rheumatoid arthritis treatment. Formulation of diclofenac sodium in fast disintegrating tablet dosage form is an appropiate alternative to enhance patient compliance and rapidly disintegrated in the mouth. This research was aimed to optimize the formulation of diclofenac sodium fast disintegrating tablet using Primojel, Primellose, and effervescent component by simplex lattice design method.Optimum region was determined by simplex lattice design with several responses i.e. hardness, friability, wetting time, in vitro and in vivo disintegration time, amount of drug released at 1 min and dissolution efficiency during 5 min using Design Expert software. The results showed that effervescent components significantly affected on an increase wetting time, in vitro and in vivo disintegration time, and the drug release. Primojel was the most dominant component affected on an increase friability, meanwhile Primellose affected on an increase hardness. The most optimum formula was obtained on Primojel 11,12 mg, Primellose 2,88 mg and effevescent components 8,00 mg.  Natrium diklofenak merupakan golongan non-steroidal anti-inflamatory drug umumnya digunakan pada pengobatan rheumatoid arthritis.Formulasi Na diklofenakdalam sediaan fast disintegrating tablet merupakan alternatif yang tepat untukmeningkatkankenyamanandancepathancur di mulut. Penelitian ini bertujuan untuk mengoptimasi formula FDT natrium diklofenak menggunakan Primojel® ,Primellose®dan komponen effervescent menggunakan metode simplex lattice design.Daerah optimum ditentukan dengan metode simplex lattice design denganrespon kekerasan, kerapuhan,wetting time, waktuhancurin vitro dan in vivo, jumlahobat yang terlepaspadamenit 1 dan dissolution efficiencyselama 5 menit menggunakan software Design Expert. Hasil penelitian menunjukkan komponen effervescentmemberikan pengaruh bermakna terhadap peningkatan wetting time, waktu hancur in vitro dan in vivo, dan pelepasan obat. Primojel® memberikan pengaruh dominan terhadap peningkatan kerapuhan dan Primellose® memberikan pengaruh dominan terhadap peningkatan kekerasan. Formula optimum diperoleh pada komposisi Primojel® 11,12 mg,Primellose® 2,88 mg dan komponen effervescent8,00 mg