This study shows that the dialectics of wisdom and folly, which owes a great deal to the relativization of reason in Renaissance culture, undergoes an original development in Marguerite de Navarre’s “secular” theater. While in these plays Marguerite uses figures of folly which inscribe themselves in the tradition represented by the late-medieval wordly fool, or Erasmus’s wise fool, she also creates the figure of the spiritual fool, who draws from both divine science and mystical ecstasy. The protagonists of four of Marguerite’s plays, Le Mallade, L’Inquisiteur, Trop, Prou, Peu, Moins, and the Comédie jouée au Mont de Marsan (written between 1535 and 1547), embody spiritual folly to an increasingly sublime degree, from the docta ignorantia u...