脱感作機構に関する実験的研究(4) 結核家兎のツベルクリン脱感作について 第5篇 全編の総括,考按並びに結論

Rabbits immunized with BCG or infected with human tubercle bacilli were continuously desensitized with Sauton culture filtrate to study the relationship between tuberculin allergy and serum antibodies. By desensitizaton the tuberculin reaction gradually decreased and became negative in some cases, while precipitins and agglutinins increased. Thus the dissociation was observed between the strength of tuberculin reaction and the quantity of serum antibodies. But a definite inter-dependence between tuberculin reaction and serum antibodies was not observed in the complement fixation test. As anticutins were not always present in the sera of desensitized rabbits, the cause of tuberculin reaction showing negative by desensitization can not be laid at the door of anticutins and from experiments on the animals, which were sensitized with two antigens, and later desensitized with two antigens, it can be said that the "dissociation" is specific in tuberculin desensitization. It is evident that such desensitization gives a higher degree of immunity against the rein-fection with Myco. tuberculosis. From these results the interrelationship between allergy and immunity has been discussed.departmental bulletin pape