Background and aim of the work: Long Term Carcinogenicity Bioassays (LTCB) are among the best instruments to strengthen the evidence on which regulatory agencies base their decision to classify harmful agents as human carcinogens, so they are fundamental to protect public health. The statistical analysis is essential to validate the results from cancer and non-cancer outcomes in carcinogenicity bioassay. This work proposes and applies some methodologies for the analysis of non-cancer outcomes, such as body weights. Methods: We use data from studies already concluded, evaluated and published: 4 bioassays aimed at testing the carcinogenic potential of Coca-Cola on Sprague-Dawley rats of different ages. The analysis of body weights of the seco...
In revising cancer risk assessment guidelines, the U.S. Environmental Protection Agency (EPA) analyz...
<div><p>The current gold-standard method for cancer safety assessment of drugs is a rodent two-year ...
AbstractA recent research article by the National Center for Computational Toxicology (NCCT) (Kleins...
Background and aim of the work: Long Term Carcinogenicity Bioassays (LTCB) are among the best instru...
The NTP lifetime rodent bioassay (LRB) is the “gold standard” for predicting human carcinogenicity. ...
The goal of human risk assessment is to decide whether a given exposure level to a particular chemic...
Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not...
Acompendiumof carcinogenesi s bioassay results organized by target organ is presented for 738 chemic...
Long-term studies in rodents are the benchmark method to assess carcinogenicity of single substances...
AbstractSub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predi...
Long-term studies in rodents are the benchmark method to assess carcinogenicity of single substances...
Due to limited human exposure data, risk classification and the consequent regulation of exposure to...
In an earlier report we developed a quantitative likelihood-based analysis of the differences in sen...
The approach to evaluating the carcinogenic potential of pharmaceuticals is a matter Of debate and h...
This paper addresses the design, conduct, and statistical analysis of carcinogenicity studies, espec...
In revising cancer risk assessment guidelines, the U.S. Environmental Protection Agency (EPA) analyz...
<div><p>The current gold-standard method for cancer safety assessment of drugs is a rodent two-year ...
AbstractA recent research article by the National Center for Computational Toxicology (NCCT) (Kleins...
Background and aim of the work: Long Term Carcinogenicity Bioassays (LTCB) are among the best instru...
The NTP lifetime rodent bioassay (LRB) is the “gold standard” for predicting human carcinogenicity. ...
The goal of human risk assessment is to decide whether a given exposure level to a particular chemic...
Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not...
Acompendiumof carcinogenesi s bioassay results organized by target organ is presented for 738 chemic...
Long-term studies in rodents are the benchmark method to assess carcinogenicity of single substances...
AbstractSub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predi...
Long-term studies in rodents are the benchmark method to assess carcinogenicity of single substances...
Due to limited human exposure data, risk classification and the consequent regulation of exposure to...
In an earlier report we developed a quantitative likelihood-based analysis of the differences in sen...
The approach to evaluating the carcinogenic potential of pharmaceuticals is a matter Of debate and h...
This paper addresses the design, conduct, and statistical analysis of carcinogenicity studies, espec...
In revising cancer risk assessment guidelines, the U.S. Environmental Protection Agency (EPA) analyz...
<div><p>The current gold-standard method for cancer safety assessment of drugs is a rodent two-year ...
AbstractA recent research article by the National Center for Computational Toxicology (NCCT) (Kleins...