Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015
- Bousquet, J.
- Anto, J. M.
- Akdis, M.
- Auffray, C.
- Keil, T.
- Momas, I.
- Postma, D. S.
- Valenta, R.
- Wickman, M.
- Cambon Thomsen, A.
- Haahtela, T.
- Lambrecht, B. N.
- Lodrup Carlsen, K. C.
- Koppelman, G. H.
- Sunyer, J.
- Zuberbier, T.
- Annesi Maesano, I.
- Arno, A.
- Bindslev Jensen, C.
- De Carlo, G.
- Forastiere, F.
- Heinrich, J.
- Kowalski, M. L.
- Maier, D.
- Melén, E.
- Palkonen, S.
- Smit, H. A.
- Standl, M.
- Wright, J.
- Asarnoj, A.
- Benet, M.
- Ballardini, N.
- Garcia Aymerich, J.
- Gehring, U.
- Guerra, S.
- Hohman, C.
- Kull, I.
- Lupinek, C.
- Pinart, M.
- Skrindo, I.
- Westman, M.
- Smagghe, D.
- Akdis, C.
- Albang, R.
- Anastasova, V.
- Anderson, N.
- Bachert, C.
- Ballereau, S.
- Ballester, F.
- Basagana, X.
- Bedbrook, A.
- Bergstrom, A.
- von Berg, A.
- Brunekreef, B.
- Burte, E.
- Carlsen, K. H.
- Chatzi, L.
- Coquet, J. M.
- Curin, M.
- Demoly, P.
- Eller, E.
- Gerhard, B.
- Hammad, H.
- von Hertzen, L.
- Hovland, V.
- Jacquemin, B.
- Just, J.
- Keller, T.
- Kerkhof, M.
- Kiss, R.
- Kogevinas, M.
- Koletzko, S.
- Lau, S.
- Lehmann, I.
- Lemonnier, N.
- Mceachan, R.
- Mäkelä, M.
- Mestres, J.
- Minina, E.
- Mowinckel, P.
- Nadif, R.
- Nawijn, M.
- Oddie, S.
- Pellet, J.
- Pin, I.
- Porta, D.
- Rancière, F.
- Rial Sebbag, A.
- Saeys, Y.
- Schuijs, M. J.
- Siroux, V.
- Tischer, C. G.
- Torrent, M.
- Varraso, R.
- De Vocht, J.
- Wenger, K.
- Wieser, S.
- Xu, C.
- FANTINI, MARIA PIA
DOIAbstract
MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered ...
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