HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis
- Yaldizli, Özgür
- Sethi, Varun
- Pardini, Matteo
- Tur, Carmen
- Mok, Kin Y.
- Muhlert, Nils
- Liu, Zheng
- Samson, Rebecca S.
- GANDINI, CLAUDIA
- Yousry, Tarek A.
- Houlden, Henry
- Hardy, John
- Miller, David H.
- Chard, Declan T.
DOIAbstract
Background: The HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim: To assess HLA-DRB*1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods: Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB*1501 haplotype was determined by genotyping (rs3135388). Results: No significant differences were observed in MRI measures between the HLA-DRB*1501 subgroups. Conclusions: The HLA-DRB*1501 haplotype is not strongly associated with MRI-visible grey matter patholog
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