Higher circulating mRNA levels of placental specific genes in a patient with placenta accreta.

At 32 weeks of gestation, a peripheral maternal blood sample was collected for measurement of mRNAs for Ki-67, KiSS-1 metastasis-suppressor (KISS1), PLAC1, PlGF, VEGF and Flt-1 genes. Amounts of mRNA samples were expressed in terms of copies per millilitre and were also measured in 32 pregnant women at 31 to 33 gestational weeks with normal placentation (controls). All the cases included in the study were dated by ultrasound in the first trimester. Copies were converted into multiples of the median (MoM) of unaffected pregnancies. Normal distribution was tested by Kolmogorov–Smirnov test. As we had only one case of placenta accreta data were examined and compared only by visual inspection.Our results are consistent with a possible involvement of KISS1, PLAC1 and VEGF genes in placenta accreta development. These results could allow a more in depth follow-up during the pregnancy in centers where molecular genetics laboratories are availabl