The state of the art of membrane protein structure prediction: from sequence to 3D structure

1. Why membrane proteins? 2 Many functions 3 Bioinformatics and membrane proteins: is it feasible to predict the 3D structure of a membrane protein? 4 Predicting the topology of membrane proteins 5 How many methods to predict membrane protein topology? 5.1 From theory to practice 6 Benchmarking the predictors of transmembrane topology 6.1 Testing on membrane proteins of known structure and topology 6.2 Topological experimental data 6.3 Validation towards experimental data 7 How many membrane proteins in the Human genome? 8 Membrane proteins and genetic diseases: PhD-SNP at work 9 Last but not least: 3D MODELLING of membrane proteins 10 What can currently be done in practice? 11 Can we improve