Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
- Pfeffer, Marc A.
- Claggett, Brian
- Diaz, Rafael
- Dickstein, Kenneth
- Gerstein, Hertzel C.
- Køber, Lars V.
- Lawson, Francesca C.
- Ping, Lin
- Wei, Xiaodan
- Lewis, Eldrin F.
- Maggioni, Aldo P.
- McMurray, John J. V.
- Probstfield, Jeffrey L.
- Riddle, Matthew C.
- Solomon, Scott D.
- Tardif, Jean-Claude
- ELIXA Investigators
- Aizenberg D
- Alvarez C
- Alvarisqueta A
- Baccaro C
- Bartolacci I
- Bordonava A
- Bustamante Labarta M
- Caccavo A
- Calella P
- Cantero M
- Codutti R
- Commendatore V
- Costamagna O
- Cuello J
- Fernandez A
- Garcia Duran R
- Gomez Vilamajo O
- Gorban De Lapertosa S
- Grinfeld D
- Hermida S
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- Amerena J
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Publication date
January 2015
DOIAbstract
Cardiovascular morbidity and mortality are higher among patients with type 2 diabetes, particularly those with concomitant cardiovascular diseases, than in most other populations. We assessed the effects of lixisenatide, a glucagon-like peptide 1-receptor agonist, on cardiovascular outcomes in patients with type 2 diabetes who had had a recent acute coronary event. METHODS: We randomly assigned patients with type 2 diabetes who had had a myocardial infarction or who had been hospitalized for unstable angina within the previous 180 days to receive lixisenatide or placebo in addition to locally determined standards of care. The trial was designed with adequate statistical power to assess whether lixisenatide was noninferior as well as super...
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