RESPON INFLAMASI SELULER PASCA PENANAMAN SUBKUTAN DEMINERALIZED FREEZE DRIED BOVINECORTICAL BONE MEMBRANE (DFDBCBM) Penelitian Experimental Labolatorik In Vivo Pada Tikus Strain Wistar

Background: One technique of ridge augmentation is Guided Bone Regeneration (GBR). GBR is a surgical procedure that uses barrier membranes with or without particulate bone grafts. It is used to enhance bone growth of the alveolus for implant placement and around peri-implant defects. The prosedures of making collagen membrane for GBR requires technology and high cost. Therefore development of Freeze Dried Demineralized Bovine Cortical Bone Membran (DFDBCBM) as an alternative collagen membrane that can be used as guided bone regeneration is important. Purpose: To determinate inflammation respon of DFDBCBM as GBR. Method: A research on inflammation respon of DFDBCBM compared by bovine pericardium membrane (Jason® membrane, Botis Dental) were done, by implanted both membrane in subcutaneous dorsum region of Wistar rats. Study of inflammation respon were observed using light microscope on specimen that stained with Hematoxilin Eosin on 2, 5 and 7 days after inplantation. Result: The result of study showed that there were no sighnificant difference on inflammation respon between DFDBCBM compared to bovine pericardium membrane (Jason® membrane, Botis Dental) after implantation (p > 0,05). Conclusion: Conclude in this study, there were no difference on inflammation respon between DFDBCBM and bovine pericardium membrane (Jason® membrane, Botis Dental). Keyword: Guided Bone Membran, Bioresorbsable Membrane, Collagen membrane, Inflamation Respon on Biomateria