In this work, we prove limitations on the known methods for designing matrix multiplication algorithms. Alman and Vassilevska Williams [Alman and Williams, 2018] recently defined the Universal Method, which substantially generalizes all the known approaches including Strassen\u27s Laser Method [V. Strassen, 1987] and Cohn and Umans\u27 Group Theoretic Method [Cohn and Umans, 2003]. We prove concrete lower bounds on the algorithms one can design by applying the Universal Method to many different tensors. Our proofs use new tools for upper bounding the asymptotic slice rank of a wide range of tensors. Our main result is that the Universal method applied to any Coppersmith-Winograd tensor CW_q cannot yield a bound on omega, the exponent of mat...