It has been well noted that Aristotle’s Meteorologica IV has played an important role in the development of alchemy because of its quasi-corpuscularian doctrines and its treatments of art and nature. This paper uncovers to what extent Renaissance commentaries on this book took into account alchemy. Many Renaissance commentators such as Agostino Nifo, Lodovico Boccadiferro and Cesare Cremonini were skeptical of the possibility of the transmutation of metals and limited their discussions to what they found in medieval commentaries. Several scholars, however, noted the utility of this book towards alchemy. By the middle of the seventeenth century, two commentators intertwined their interpretations with alchemy. Girolamo Trimarchi, followin...