International audienceGlaciers are among the best terrestrial climate indicators, an important water resource in mountains1,2 and a major contributor to global sea level rise3,4. In the Hindu Kush - Karakoram - Himalaya region (HKKH), a paucity of appropriate glacier data has prevented a comprehensive assessment of current regional mass balance5. However, there are indirect evidences of a complex pattern of glacial responses5-8 in reaction to heterogeneous climate change signals9. Here, we provide the first coherent data set of detailed glacier thickness changes over the HKKH during 2003-2009 by combining satellite laser altimetry and a global elevation model. In the eastern, central and south-western parts of the HKKH, glacier wastage is w...