Programming is laborious. A long-standing goal is to reduce this cost through automation. Genetic Improvement (GI) is a new direction for achieving this goal. It applies search to the task of program improvement. The research conducted in this thesis applies GI to program optimisation and to enable program optimisation. In particular, it focuses on automatic code optimisation for complex managed runtimes, such as Java and Ethereum Virtual Machines. We introduce the term Darwinian Data Structures (DDS) for the data structures of a program that share a common interface and enjoy multiple implementations. We call them Darwinian since we can subject their implementations to the survival of the fittest. We introduce ARTEMIS, a novel cloud-based ...