Budding yeast Saccharomyces cerevisiae contains a group of proteins named ZMM that constitutes a link between recombination and Synaptonemal Complex (SC) assembly. Yeast mutants that lack ZMM proteins have defects in recombination, SC formation and nuclear division progression. Meiotic cell cycle progression in zmm mutants is modulated by temperature. This conditional behavior is different at high and low temperatures. In my work so far, I have tried to identify new zmm-like genes involved in meiosis. To that end, I have carried out a genome-wide screen in the budding yeast S. cerevisiae. I have identified sporulation temperature sensitive zmm-like truncation mutants by using mini-transposon mediated random insertional mutagenesis approach....
Thesis (Ph.D.), Department of Biological Systems Engineering, Washington State UniversityMeiosis is ...
High-throughput studies of the 6,200 genes of Saccharomyces cerevisiae have provided valuable data r...
Although genetic distances are often assumed to be proportional to physical distances, chromosomal r...
Budding yeast Saccharomyces cerevisiae contains a group of proteins named ZMM that constitutes a lin...
BACKGROUND: In many organisms, homologous chromosomes rely upon recombination-mediated linkages, ter...
Proper segregation of chromosomes in Meiosis I requires proper function of the Synaptonemal Complex ...
Chromosome miss-segregation during meiosis is a major factor contributing to birth defects as well a...
Genetic recombination is essential in order to create diversity amongst all of the genetic informati...
The production of gametes in Saccharomyces cerevisiae via meiosis is under strict regulatory control...
Sexually reproducing organisms employ a specialized cell division called meiosis to form unique, hap...
AbstractBackground: Meiosis is the process by which gametes are generated with half the ploidy of so...
During meiosis, one round of DNA replication is followed by two rounds of chromosome segregation, pr...
SummaryMeiosis is a specialized form of cell division by which sexually reproducing diploid organism...
BACKGROUND:In many organisms, homologous chromosomes rely upon recombination-mediated linkages, term...
Meiotic recombination in Saccharomyces cerevisiae is initiated by the formation of DNA double strand...
Thesis (Ph.D.), Department of Biological Systems Engineering, Washington State UniversityMeiosis is ...
High-throughput studies of the 6,200 genes of Saccharomyces cerevisiae have provided valuable data r...
Although genetic distances are often assumed to be proportional to physical distances, chromosomal r...
Budding yeast Saccharomyces cerevisiae contains a group of proteins named ZMM that constitutes a lin...
BACKGROUND: In many organisms, homologous chromosomes rely upon recombination-mediated linkages, ter...
Proper segregation of chromosomes in Meiosis I requires proper function of the Synaptonemal Complex ...
Chromosome miss-segregation during meiosis is a major factor contributing to birth defects as well a...
Genetic recombination is essential in order to create diversity amongst all of the genetic informati...
The production of gametes in Saccharomyces cerevisiae via meiosis is under strict regulatory control...
Sexually reproducing organisms employ a specialized cell division called meiosis to form unique, hap...
AbstractBackground: Meiosis is the process by which gametes are generated with half the ploidy of so...
During meiosis, one round of DNA replication is followed by two rounds of chromosome segregation, pr...
SummaryMeiosis is a specialized form of cell division by which sexually reproducing diploid organism...
BACKGROUND:In many organisms, homologous chromosomes rely upon recombination-mediated linkages, term...
Meiotic recombination in Saccharomyces cerevisiae is initiated by the formation of DNA double strand...
Thesis (Ph.D.), Department of Biological Systems Engineering, Washington State UniversityMeiosis is ...
High-throughput studies of the 6,200 genes of Saccharomyces cerevisiae have provided valuable data r...
Although genetic distances are often assumed to be proportional to physical distances, chromosomal r...