2. Summary In Drosophila melanogaster the transcriptional activity of the male X chromosome is upregulated to compensate for the reduced dosage of X-linked genes as compared to the two X chromosomes in females. This process is mediated by the Dosage Compensation Complex (DCC), a ribonucleoprotein complex consisting of five proteins (MSL1, MSL2, MSL3, MOF and MLE) and two non-coding RNAs (roX1 and roX2). The DCC preferentially localizes on the X chromosomes in males where it doubles its transcription rate. Two enzymes are associated with the DCC: the acetyltransferase MOF, specific for the lysine 16 of H4 (H4-K16), and the DNA/RNA helicase MLE. Genetic experiments demonstrated that both activities are required for dosage compensation in mal...
Photosynthesis is a fundamental and vital physiological process in plants that occurs in the chlorop...
The clinical course of renal cell carcinoma (RCC) shows a high variability. Prognostic markers are e...
Die Cystische Fibrose (CF) ist eine autosomal-rezessive vererbare Erkrankung, die vorwiegendden kauk...
2. Summary In Drosophila melanogaster the transcriptional activity of the male X chromosome is upre...
Peritubular cells are the cellular components of the wall of the seminiferous tubules in the testis....
With several clinical approvals, the field of oligonucleotide therapeutics has come of age in the la...
With several clinical approvals, the field of oligonucleotide therapeutics has come of age in the la...
The archaeal transcription machinery encompasses one multi-subunit RNA polymerase (RNAP), resembling...
The clinical course of renal cell carcinoma (RCC) shows a high variability. Prognostic markers are e...
Inosine is a guanosine analogue that when is found at the wobble position of the tRNAs (I34) expands...
Eukaryotic genomes make use of nucleosomes to considerably reduce their packaging volumes. As a cons...
Title and Contents I 1\. Introduction 1 2\. Aims 23 3\. Materials and Methods 25 4\. Res...
Aneuploidy or imbalanced chromosome content is the cause of pathological conditions such as Down's s...
Since colorectal cancer is the second most common tumor entity in Europe there is a great need for r...
Eukaryotic genomes make use of nucleosomes to considerably reduce their packaging volumes. As a cons...
Photosynthesis is a fundamental and vital physiological process in plants that occurs in the chlorop...
The clinical course of renal cell carcinoma (RCC) shows a high variability. Prognostic markers are e...
Die Cystische Fibrose (CF) ist eine autosomal-rezessive vererbare Erkrankung, die vorwiegendden kauk...
2. Summary In Drosophila melanogaster the transcriptional activity of the male X chromosome is upre...
Peritubular cells are the cellular components of the wall of the seminiferous tubules in the testis....
With several clinical approvals, the field of oligonucleotide therapeutics has come of age in the la...
With several clinical approvals, the field of oligonucleotide therapeutics has come of age in the la...
The archaeal transcription machinery encompasses one multi-subunit RNA polymerase (RNAP), resembling...
The clinical course of renal cell carcinoma (RCC) shows a high variability. Prognostic markers are e...
Inosine is a guanosine analogue that when is found at the wobble position of the tRNAs (I34) expands...
Eukaryotic genomes make use of nucleosomes to considerably reduce their packaging volumes. As a cons...
Title and Contents I 1\. Introduction 1 2\. Aims 23 3\. Materials and Methods 25 4\. Res...
Aneuploidy or imbalanced chromosome content is the cause of pathological conditions such as Down's s...
Since colorectal cancer is the second most common tumor entity in Europe there is a great need for r...
Eukaryotic genomes make use of nucleosomes to considerably reduce their packaging volumes. As a cons...
Photosynthesis is a fundamental and vital physiological process in plants that occurs in the chlorop...
The clinical course of renal cell carcinoma (RCC) shows a high variability. Prognostic markers are e...
Die Cystische Fibrose (CF) ist eine autosomal-rezessive vererbare Erkrankung, die vorwiegendden kauk...