Currently patients with diabetes receive most of their treatments, including insulin, subcutaneously. Developing a method to orally deliver proteins, peptides, and potentially other therapeutics has the ability to increase patient compliance by making treatments easier to administer. Utilizing the Vitamin B12 uptake pathway is one proposed method of oral delivery of protein therapeutics. We investigated a way to synthesize a carboxylic acid derivative of Vitamin B12 (B12) that could increase the ease of its conjugation to proteins and peptides. The 5’-position of the ribose tail of B12 was oxidized using excess 2-iodoxybenzoic acid (IBX) and 2-hydroxypyridine (HYP). The synthesis of this B12 derivative allows for peptides, proteins, and oth...
This thesis describes synthetic approaches for improving the efficiency of transport of small molecu...
Mucosal delivery of biotherapeutics as a non-invasive means of delivery could potentially be enhance...
408-415The daily multiple insulin injection is the line of treatment for diabetes mellitus. As the o...
Protein therapeutics like insulin and glucagon-like peptide-1 analogues are currently used as inject...
Vitamin B12 is an essential biomolecule for humans and it is only produced by certain microorganisms...
Vitamin B12 supplementation in specific clinical conditions in diabetic patients has been recommende...
Abstract This thesis addresses several questions focused on the vitamin B12 (B12) dietary uptake pat...
This project aimed to create a novel oral tetanus vaccine by exploiting the B12 uptake pathway. Whil...
The two main aims of this thesis have been; 1. To examine the structural changes which alter the bin...
Obesity has become a worldwide epidemic, with nearly 40% of the adult population (age 18+) being con...
The tumour cells take up proportionally more vitamin B12 than non-proliferating cells due to an incr...
This short review highlights the author’s group research on modified vitamin B[Formula: see text] de...
Injections of hPYY(3-36) have shown positive effects on appetite regulation. With nearly 400 million...
Importance of the field: Vitamin B12 (B12) is a rare and vital micronutrient for which mammals have ...
Photoactivatable therapeutics are targeted light-activated drug delivery systems composed of a thera...
This thesis describes synthetic approaches for improving the efficiency of transport of small molecu...
Mucosal delivery of biotherapeutics as a non-invasive means of delivery could potentially be enhance...
408-415The daily multiple insulin injection is the line of treatment for diabetes mellitus. As the o...
Protein therapeutics like insulin and glucagon-like peptide-1 analogues are currently used as inject...
Vitamin B12 is an essential biomolecule for humans and it is only produced by certain microorganisms...
Vitamin B12 supplementation in specific clinical conditions in diabetic patients has been recommende...
Abstract This thesis addresses several questions focused on the vitamin B12 (B12) dietary uptake pat...
This project aimed to create a novel oral tetanus vaccine by exploiting the B12 uptake pathway. Whil...
The two main aims of this thesis have been; 1. To examine the structural changes which alter the bin...
Obesity has become a worldwide epidemic, with nearly 40% of the adult population (age 18+) being con...
The tumour cells take up proportionally more vitamin B12 than non-proliferating cells due to an incr...
This short review highlights the author’s group research on modified vitamin B[Formula: see text] de...
Injections of hPYY(3-36) have shown positive effects on appetite regulation. With nearly 400 million...
Importance of the field: Vitamin B12 (B12) is a rare and vital micronutrient for which mammals have ...
Photoactivatable therapeutics are targeted light-activated drug delivery systems composed of a thera...
This thesis describes synthetic approaches for improving the efficiency of transport of small molecu...
Mucosal delivery of biotherapeutics as a non-invasive means of delivery could potentially be enhance...
408-415The daily multiple insulin injection is the line of treatment for diabetes mellitus. As the o...