Tierexperimentelle Untersuchungen mit Radium-224

The examinations on early damage on the skeleton were carried out in the proximal fibia metaphysis of rats and mice after incorporation of 224Ra. In addition to the conventional histological examinations, enzyme-histochemical, electrone-microscopic, and autoradiographical methods of examination were applied. The results are briefly shown. The examinations concerning the question of delayed damage were mainly carried out on female NMRI-mice which had been administered intraperitoneally 1.cal, electrone-microscopic, and autoradiographical methods of examination were applied. The results are briefly shown. The examinations concerning the question of delayed damage were mainly carried out on female NMRI-mice which had been administered intraperitoneally 1,0 - 50 μCi/kg 224Ra. According to this, the osteosarcome incidency was between 7 and 20% without clear dose dependency. The skeletal distribution of osteosarcomas, however, was dose-dependent. In the experiments with repeated injection of 224Ra, an increase in the multifocal osteosarcomas could be observed. The results of these experiments presented here cannot be directly applied to men