Wrong-way driving (WWD) has been a constant traffic safety problem in certain types of roads. These crashes are mostly associated with fatal or severe injuries. This study aims to determine associations between various factors in the WWD crashes. Past studies on WWD crashes used either descriptive statistics or logistic regression to identify the impact of key contributing factors on frequency and/or severity of crashes. Machine learning and data mining approaches are resourceful in determining interesting and non-trivial patterns from complex datasets. This study employed association rules ‘Eclat’ algorithm to determine the interactions between different factors that result in WWD crashes. This study analyzed five years (2010–2014) of Loui...