A novel polythyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis
- Shao, Wei
- Paul, Arghya
- Chahal, Parminder S.
- Mena, Jimmy A.
- Montes, Johnny
- Kamen, Amine
- Prakash, Satya
DOIAbstract
Systemic delivery of small interfering RNA (siRNA) is limited by its poor stability and limited cell-penetrating properties. To overcome these limitations, we designed an efficient siRNA delivery system using polyethyleneimine-coated virus-like particles derived from adeno-associated virus type 2 (PEI-AAV2-VLPs)
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