Add to ORKGDespite the discrepancies observed between the data generated from humans and animals, it is a usual practice that the results obtained from animal models are extrapolated on humans. This review stresses that while animal models are essential for the research and development, a critical caution needs to be practiced in interpreting the results. Uncritical reliance on the results of animal experimentation can be dangerously misleading and has resulted in damages to human health in several cases. This review also discusses the role of certain confounding factors in using animal models due to which appropriate precautions need to be taken while deciding to conduct a study using animal models and caution is warranted in extrapolating the data o...
Background:Today, thousands of animal experimentations are performed to develop innovative drugs.But...
Rodents, in particular Mus musculus, have a long and invaluable history as models for human diseases...
Animal use continues to be central to preclinical drug development, in spite of a lack of its demons...
Despite the discrepancies observed between the data generated from humans and animals, it is a usual...
Other animals, such as mice, rats, rabbits, dogs and monkeys, are widely used as surrogates for huma...
Abstract Background The pharmaceutical industry is in the midst of a productivity crisis and rates o...
Widespread reliance on animal models during preclinical research and toxicity testing assumes their ...
The assumption that animal models are reasonably predictive of human outcomes provides the basis for...
Every year, and in countries around the world, significant time and resources are devoted to the nob...
The value of animal experiments for predicting the effectiveness of treatment strategies in clinical...
The development of efficient ways to predict, prevent, diagnose and treat human diseases is of great...
Biomedical science is dependent on standardised rodents. These lab-rats and lab-mice are different f...
Reports of a reproducibility crisis combined with a high attrition rate in the pharmaceutical indust...
Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is reliable, t...
Due to limited human exposure data, risk classification and the consequent regulation of exposure to...
Background:Today, thousands of animal experimentations are performed to develop innovative drugs.But...
Rodents, in particular Mus musculus, have a long and invaluable history as models for human diseases...
Animal use continues to be central to preclinical drug development, in spite of a lack of its demons...
Despite the discrepancies observed between the data generated from humans and animals, it is a usual...
Other animals, such as mice, rats, rabbits, dogs and monkeys, are widely used as surrogates for huma...
Abstract Background The pharmaceutical industry is in the midst of a productivity crisis and rates o...
Widespread reliance on animal models during preclinical research and toxicity testing assumes their ...
The assumption that animal models are reasonably predictive of human outcomes provides the basis for...
Every year, and in countries around the world, significant time and resources are devoted to the nob...
The value of animal experiments for predicting the effectiveness of treatment strategies in clinical...
The development of efficient ways to predict, prevent, diagnose and treat human diseases is of great...
Biomedical science is dependent on standardised rodents. These lab-rats and lab-mice are different f...
Reports of a reproducibility crisis combined with a high attrition rate in the pharmaceutical indust...
Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is reliable, t...
Due to limited human exposure data, risk classification and the consequent regulation of exposure to...
Background:Today, thousands of animal experimentations are performed to develop innovative drugs.But...
Rodents, in particular Mus musculus, have a long and invaluable history as models for human diseases...
Animal use continues to be central to preclinical drug development, in spite of a lack of its demons...