Formulasi Sediaan Sabun Cair Ekstrak Daun Sirih Hijau (Piper betle L.) sebagai Antifungi Penyebab Kandidiasis pada Kulit

FORMULATION OF LIQUID SOAP FORMING OF GREEN SIRIH LEAF EXTRACT (Piper betle L.) AS ANTIFUNGI CAUSE OF CANDIDIASIS ON SKIN Zuhroul Fauziatul Umri Departement of Pharmacy, Faculty of Mathematic and Science Sebelas Maret University ABSTRACT Candida sp. is the most cause of onychomycosis infection including Candida albicans which causes candidiasis. The use of synthetic antimicroba can cause serious side effects so the community started looking for natural medicines that are believed to have less side effects. This study aim to know the existence of antimicroba activity against the growth of Candida albicans of green sirih leaf extract and how the diferences between both the formula and between the results of physical properties. This study was conducted with cup-plate technique by doing the measurement of the diameter of inhibition area (DDH) the grouwth of Candida albicansi by concentration of 15%, 20% and 25% extract of green sirih leafe with positive control nystatin. The DDH data were analyzed using One Way ANOVA. Liquid soap forming of green sirih leaf extract can formed inhibition diameter with a maximum DDH in sequence 20 mm at concentration 20%. The results of the statistical analysis of difference concentration on the liquid soap formingshows the results value og Sig. < 0,050 which indicates there is significants differences antimicroba activity between extract. The difference between DDH with viscosity, analyzed shows that the significant differences in all the formulas. Keywords : Candida albicans, liquid soap forming, cup-plate technique, nystati