Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
- Draisma, Harmen H. M.
- Pool, Rene
- Kobl, Michael
- Jansen, Rick
- Petersen, Ann-Kristin
- Vaarhorst, Anika A. M.
- Yet, Idil
- Haller, Toomas
- Demirkan, Ayse
- Esko, Tonu
- Zhu, Gu
- Boehringer, Stefan
- Beekman, Marian
- Klinken, Jan Bert van
- Roemisch-Margl, Werner
- Prehn, Cornelia
- Adamski, Jerzy
- Craen, Anton J. M. de
- Leeuwen, Elisabeth M. van
- Amin, Najaf
- Dharuri, Harish
- Westra, Harm-Jan
- Franke, Lude
- Geus, Eco J. C. de
- Hottenga, Jouke Jan
- Willemsen, Gonneke
- Henders, Anjali K.
- Montgomery, Grant W.
- Nyholt, Dale R.
- Whitfield, John B.
- Penninx, Brenda W.
- Spector, Tim D.
- Metspalu, Andres
- Slagboom, P. Eline
- Dijk, Ko Willems van
- Hoen, Peter A. C. 't
- Strauch, Konstantin
- Martin, Nicholas G.
- Ommen, Gert-Jan B. van
- Illig, Thomas
- Bell, Jordana T.
- Mangino, Massimo
- Suhre, Karsten
- McCarthy, Mark I.
- Gieger, Christian
- Isaacs, Aaron
- Duijn, Cornelia M. van
- Boomsma, Dorret I.
DOIAbstract
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7, 478 individuals of European descent, we find 4, 068 genome-and metabolome-wide significant (Z-test, P<1.09 x 10(-9)) associations between single-nucleotide polymorphisms (SNPs) and metabolites, involving 59 independent SNPs and 85 metabolites. Five of the fifty-nine independent SNPs are new for serum metabolite levels, and were followed-up for replication in an independent sample (N = 1, 182). The...
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