Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
- Hou, L.
- Bergen, S. E.
- Akula, N.
- Song, J.
- Hultman, C. M.
- Landen, M.
- Adli, M.
- Alda, M.
- Ardau, R.
- Arias, B.
- Aubry, J. M.
- Backlund, L.
- Badner, J. A.
- Barrett, T. B.
- Bauer, M.
- Baune, B. T.
- Bellivier, F.
- Benabarre, A.
- Bengesser, S.
- Berrettini, W. H.
- Bhattacharjee, A. K.
- Biernacka, J. M.
- Birner, A.
- Bloss, C. S.
- Brichant-Petitjean, C.
- Bui, E. T.
- Byerley, W.
- Cervantes, P.
- Chillotti, C.
- Cichon, S.
- Colom, F.
- Coryell, W.
- Craig, D. W.
- Cruceanu, C.
- Czerski, P. M.
- Davis, T.
- Dayer, A.
- Degenhardt, F.
- Del Zompo, M.
- DePaulo, J. R.
- Edenberg, H. J.
- Etain, B.
- Falkai, P.
- Foroud, T.
- Forstner, A. J.
- Frisen, L.
- Frye, M. A.
- Fullerton, J. M.
- Gard, S.
- Garnham, J. S.
- Gershon, E. S.
- Goes, F. S.
- Greenwood, T. A.
- Grigoroiu-Serbanescu, M.
- Hauser, J.
- Heilbronner, U.
- Heilmann-Heimbach, S.
- Herms, S.
- Hipolito, M.
- Hitturlingappa, S.
- Hoffmann, P.
- Hofmann, A.
- Jamain, S.
- Jimenez, E.
- Kahn, J. P.
- Kassem, L.
- Kelsoe, J. R.
- Kittel-Schneider, S.
- Kliwicki, S.
- Koller, D. L.
- Konig, B.
- Lackner, N.
- Laje, G.
- Lang, M.
- Lavebratt, C.
- Lawson, W. B.
- Leboyer, M.
- Leckband, S. G.
- Liu, C.
- Maaser, A.
- Mahon, P. B.
- Maier, W.
- Maj, M.
- Manchia, M.
- Martinsson, L.
- McCarthy, M. J.
- McElroy, S. L.
- McInnis, M. G.
- McKinney, R.
- Mitchell, P. B.
- Mitjans, M.
- Mondimore, F. M.
- Monteleone, P.
- Muhleisen, T. W.
- Nievergelt, C. M.
- Nothen, M. M.
- Novak, T.
- Nurnberger, J. I.
- Jr.,
- Nwulia, E. A.
- Osby, U.
- Pfennig, A.
- Potash, J. B.
- Propping, P.
- Reif, A.
- Reininghaus, E.
- Rice, J.
- Rietschel, M.
- Rouleau, G. A.
- Rybakowski, J. K.
- Schalling, M.
- Scheftner, W. A.
- Schofield, P. R.
- Schork, N. J.
- Schulze, T. G.
- Schumacher, J.
- Schweizer, B. W.
- Severino, G.
- Shekhtman, T.
- Shilling, P. D.
- Simhandl, C.
- Slaney, C. M.
- Smith, E. N.
- Squassina, A.
- Stamm, T.
- Stopkova, P.
- Streit, F.
- Strohmaier, J.
- Szelinger, S.
- Tighe, S. K.
- Tortorella, A.
- Turecki, G.
- Vieta, E.
- Volkert, J.
- Witt, S. H.
- Wright, A.
- Zandi, P. P.
- Zhang, P.
- Zollner, S.
- McMahon, F. J.
DOIAbstract
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of <9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used approximately 2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide s...
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