Genome-wide association study identifies 30 loci associated with bipolar disorder
- Stahl, E.
- Breen, G.
- Forstner, A.
- McQuillin, A.
- Ripke, S.
- Trubetskoy, V.
- Mattheisen, M.
- Wang, Y.
- Coleman, J.
- Gaspar, H.
- de Leeuw, C.
- Steinberg, S.
- Pavlides, J.
- Trzaskowski, M.
- Byrne, E.
- Pers, T.
- Holmans, P.
- Richards, A.
- Abbott, L.
- Agerbo, E.
- Akil, H.
- Albani, D.
- Alliey-Rodriguez, N.
- Als, T.
- Anjorin, A.
- Antilla, V.
- Awasthi, S.
- Badner, J.
- Baekvad-Hansen, M.
- Barchas, J.
- Bass, N.
- Bauer, M.
- Belliveau, R.
- Bergen, S.
- Pedersen, C.
- Boen, E.
- Boks, M.
- Boocock, J.
- Budde, M.
- Bunney, W.
- Burmeister, M.
- Bybjerg-Grauholm, J.
- Byerley, W.
- Casas, M.
- Cerrato, F.
- Cervantes, P.
- Chambert, K.
- Charney, A.
- Chen, D.
- Churchhouse, C.
- Clarke, T.
- Coryell, W.
- Craig, D.
- Cruceanu, C.
- Curtis, D.
- Czerski, P.
- Dale, A.
- de Jong, S.
- Degenhardt, F.
- Del-Favero, J.
- DePaulo, J.
- Djurovic, S.
- Dobbyn, A.
- Dumont, A.
- Elvsashagen, T.
- Escott-Price, V.
- Fan, C.
- Fischer, S.
- Flickinger, M.
- Foroud, T.
- Forty, L.
- Frank, J.
- Fraser, C.
- Freimer, N.
- Frisen, L.
- Gade, K.
- Gage, D.
- Garnham, J.
- Giambartolomei, C.
- Pedersen, M.
- Goldstein, J.
- Gordon, S.
- Gordon-Smith, K.
- Green, E.
- Green, M.
- Greenwood, T.
- Grove, J.
- Guan, W.
- Guzman-Parra, J.
- Hamshere, M.
- Hautzinger, M.
- Heilbronner, U.
- Herms, S.
- Hipolito, M.
- Hoffmann, P.
- Holland, D.
- Huckins, L.
- Jamain, S.
- Johnson, J.
- Jureus, A.
- Kandaswamy, R.
- Karlsson, R.
- Kennedy, J.
- Kittel-Schneider, S.
- Knowles, J.
- Kogevinas, M.
- Koller, A.
- Kupka, R.
- Lavebratt, C.
- Lawrence, J.
- Lawson, W.
- Leber, M.
- Lee, P.
- Levy, S.
- Li, J.
- Liu, C.
- Lucae, S.
- Maaser, A.
- MacIntyre, D.
- Mahon, P.
- Maier, W.
- Martinsson, L.
- McCarroll, S.
- McGuffin, P.
- McInnis, M.
- Mckay, J.
- Medeiros, H.
- Medland, S.
- Meng, F.
- Milani, L.
- Montgomery, G.
- Morris, D.
- Muhleisen, T.
- Mullins, N.
- Nguyen, H.
- Nievergelt, C.
- Adolfsson, A.
- Nwulia, E.
- O'Donovan, C.
- Loohuis, L.
- Ori, A.
- Oruc, L.
- Osby, U.
- Perlis, R.
- Perry, A.
- Andrea, P.
- Potash, J.
- Purcell, S.
- Regeer, E.
- Reif, A.
- Reinbold, C.
- Rice, J.
- Rivas, F.
- Rivera, M.
- Roussos, P.
- Ruderfer, D.
- Ryu, E.
- Sanchez-Mora, C.
- Schatzberg, A.
- Scheftner, W.
- Schork, N.
- Weickert, C.
- Shehktman, T.
- Shilling, P.
- Sigurdsson, E.
- Slaney, C.
- Smeland, O.
- Sobell, J.
- Hansen, C.
- Spijker, A.
- St Clair, D.
- Steffens, M.
- Strauss, J.
- Streit, F.
- Strohmaier, J.
- Szelinger, S.
- Thompson, R.
- Thorgeirsson, T.
- Treutlein, J.
- Vedder, H.
- Wang, W.
- Watson, S.
- Weickert, T.
- Witt, S.
- Xi, S.
- Xu, W.
- Young, A.
- Zandi, P.
- Zhang, P.
- Zollner, S.
- Adolfsson, R.
- Agartz, I.
- Alda, M.
- Backlund, L.
- Baune, B.
- Bellivier, F.
- Berrettini, W.
- Biernacka, J.
- Blackwood, D.
- Boehnke, M.
- Borglum, A.
- Corvin, A.
- Craddock, N.
- Daly, M.
- Dannlowski, U.
- Esko, T.
- Etain, B.
- Frye, M.
- Fullerton, J.
- Gershon, E.
- Gill, M.
- Goes, F.
- Grigoroiu-Serbanescu, M.
- Hauser, J.
- Hougaard, D.
- Hultman, C.
- Jones, I.
- Jones, L.
- Kahn, R.
- Kirov, G.
- Landen, M.
- Leboyer, M.
- Lewis, C.
- Li, Q.
- Lissowska, J.
- Martin, N.
- Mayoral, F.
- McElroy, S.
- McIntosh, A.
- McMahon, F.
- Melle, I.
- Metspalu, A.
- Mitchell, P.
- Morken, G.
- Mors, O.
- Mortensen, P.
- Muller-Myhsok, B.
- Myers, R.
- Neale, B.
- Nimgaonkar, V.
- Nordentoft, M.
- Noethen, M.
- O'Donovan, M.
- Oedegaard, K.
- Owen, M.
- Paciga, S.
- Pato, C.
- Pato, M.
- Posthuma, D.
- Ramos-Quiroga, J.
- Ribases, M.
- Rietschel, M.
- Rouleau, G.
- Schalling, M.
- Schofield, P.
- Schulze, T.
- Serretti, A.
- Smoller, J.
- Stefansson, H.
- Stefansson, K.
- Stordal, E.
- Sullivan, P.
- Turecki, G.
- Vaaler, A.
- Vieta, E.
- Vincent, J.
- Werge, T.
- Nurnberger, J.
- Wray, N.
- Di Florio, A.
- Edenberg, H.
- Cichon, S.
- Ophoff, R.
- Scott, L.
- Andreassen, O.
- Kelsoe, J.
- Sklar, P.
Publication date
May 2019
DOIAbstract
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 x 10(-4) in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 x 10(-8)) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pa...
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