Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
- Dedic, N.
- Kühne, C.
- Jakovcevski, M.
- Hartmann, J.
- Genewsky, A.
- Gomes, K.
- Anderzhanova, E.
- Pöhlmann, M.
- Chang, S.
- Kolarz, A.
- Vogl, A.
- Dine, J.
- Metzger, M.
- Schmid, B.
- Almada, R.
- Ressler, K.
- Wotjak, C.
- Grinevich, V.
- Chen, A.
- Schmidt, M.
- Wurst, W.
- Refojo, D.
- Deussing, J.
Publication date
January 2018
DOI Publisher
Springer Science and Business Media LLCAbstract
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release
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