Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-related psychopathologies such as depression and anxiety. Although most studies have linked CRH/CRH receptor 1 signaling to aversive, stress-like behavior, recent work has revealed a crucial role for distinct CRH circuits in maintaining positive emotional valence and appetitive responses under baseline conditions. Here we addressed whether deletion of CRH, specifically from GABAergic forebrain neurons (Crh(CKO-GABA) mice) differentially affects general behavior under baseline and chronic stress conditions. Expression mapping in Crh(CKO-GAB)A mice revealed absence of Crh in GABAergic neurons of the cortex and limbic regions including the hippocamp...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-rela...
Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-rela...
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophys...
A long-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates ne...
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophys...
The bed nucleus of the stria terminalis (BNST) is a forebrain region highly responsive to stress tha...
The bed nucleus of the stria terminalis (BNST) is a forebrain region highly responsive to stress tha...
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophys...
Corticotropin-releasing hormone plays an important role in the coordination of various responses to ...
Corticotropin-releasing hormone plays an important role in the coordination of various responses to ...
Corticotropin-releasing hormone (CRH) neurons in the paraventricular hypothalamic nucleus (PVH) are...
Dysregulated corticotropin-releasing hormone (CRH)-circuits have been implicated in the pathophysiol...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-rela...
Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-rela...
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophys...
A long-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates ne...
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophys...
The bed nucleus of the stria terminalis (BNST) is a forebrain region highly responsive to stress tha...
The bed nucleus of the stria terminalis (BNST) is a forebrain region highly responsive to stress tha...
Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophys...
Corticotropin-releasing hormone plays an important role in the coordination of various responses to ...
Corticotropin-releasing hormone plays an important role in the coordination of various responses to ...
Corticotropin-releasing hormone (CRH) neurons in the paraventricular hypothalamic nucleus (PVH) are...
Dysregulated corticotropin-releasing hormone (CRH)-circuits have been implicated in the pathophysiol...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underl...