Today's most widely exploited applications are the web browsers and document readers we use every day. The immediate goal of these attacks is to compromise target systems by executing a snippet of malicious code in the context of the exploited application. Technical tactics used to achieve this can be classified as either code injection - wherein malicious instructions are directly injected into the vulnerable program - or code reuse, where bits of existing program code are pieced together to form malicious logic. In this thesis, I present a new code reuse strategy that bypasses existing and up-and-coming mitigations, and two methods for detecting attacks by identifying the presence of code injection or reuse payloads. Fine-grained address ...