The total synthesis of (+)-irciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis. In addition, efforts toward a second generation formal synthesis are described
Polyketides constitute a group of highly structurally diverse and biologically active natural produc...
Creating tools to streamline the synthesis of organic molecules is essential for the development of ...
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 i...
The total synthesis of (+)-irciniastatin A (psymberin) is reported in 19 steps and 6% overall yield....
The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield...
The dissertation herein presents the first total synthesis of (-)-irciniastatin B in conjunction wit...
The dissertation contained herein presents a first- and second-generation approach to (+)-irciniasta...
The dissertation herein presents the first total synthesis of (-)-irciniastatin B in conjunction wit...
The dissertation herein presents the first total synthesis of (-)-irciniastatin B in conjunction wit...
A unified synthetic strategy to access (+)-irciniastatin A (a.k.a. psymberin) and (−)-irciniastatin ...
The route to the key bicyclic intermediate was streamlined to eight steps in 16% yield, using a TMSI...
The total synthesis of the originally proposed structure of briarellin J is reported in twenty-three...
The enantioselective total synthesis of spirofungins A and B is reported in 14 steps over the longes...
Progress towards the total synthesis of pyrancin, a structurally-unique member of the annonaceous ac...
Efforts towards (+)-sorangicin A, a previously unprepared antibiotic macrolide, are reported. A modu...
Polyketides constitute a group of highly structurally diverse and biologically active natural produc...
Creating tools to streamline the synthesis of organic molecules is essential for the development of ...
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 i...
The total synthesis of (+)-irciniastatin A (psymberin) is reported in 19 steps and 6% overall yield....
The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield...
The dissertation herein presents the first total synthesis of (-)-irciniastatin B in conjunction wit...
The dissertation contained herein presents a first- and second-generation approach to (+)-irciniasta...
The dissertation herein presents the first total synthesis of (-)-irciniastatin B in conjunction wit...
The dissertation herein presents the first total synthesis of (-)-irciniastatin B in conjunction wit...
A unified synthetic strategy to access (+)-irciniastatin A (a.k.a. psymberin) and (−)-irciniastatin ...
The route to the key bicyclic intermediate was streamlined to eight steps in 16% yield, using a TMSI...
The total synthesis of the originally proposed structure of briarellin J is reported in twenty-three...
The enantioselective total synthesis of spirofungins A and B is reported in 14 steps over the longes...
Progress towards the total synthesis of pyrancin, a structurally-unique member of the annonaceous ac...
Efforts towards (+)-sorangicin A, a previously unprepared antibiotic macrolide, are reported. A modu...
Polyketides constitute a group of highly structurally diverse and biologically active natural produc...
Creating tools to streamline the synthesis of organic molecules is essential for the development of ...
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 i...
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