Two recent papers in Science reported the X-ray structures of the large, organizationally distinct animal and fungal fatty acid synthases at 5 Å. These new structural insights have unexpected implications for enzyme function for the other “iterative” and “assembly line” megasynthases
Megasynthases are large multienzyme proteins that produce a plethora of important natural compounds ...
SummaryIn yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out...
The yeast fatty acid synthase (FAS) is a barrel-shaped 2.6 MDa complex. Upon barrel-formation, two m...
Two recent papers in Science reported the X-ray structures of the large, organizationally distinct a...
In all organisms, fatty acid synthesis is achieved in variations of a common cyclic reaction pathway...
All steps of fatty acid synthesis in fungi are catalyzed by the fatty acid synthase, which forms a 2...
The homodimeric mammalian fatty acid synthase is one of the most complex cellular multienzymes, in t...
Eukaryotic fatty acid synthases (FASs) are huge multifunctional enzymes that carry out all enzymatic...
On page 1667 of this issue, Stuart Smith and colleagues [1] demonstrate that the animal fatty acid s...
Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesi...
Fatty acids are one of the most abundant lipids in the cell. Cells use them to build biological memb...
The metazoan cytosolic fatty acid synthase (FAS) contains all of the enzymes required for de novo fa...
Modularity is an aspect of a decomposable system with a coordinating authority that acts as a glue w...
Fungal fatty acid synthase (fFAS) is a key paradigm for the evolution of complex multienzymes. Its 4...
The de novo synthesis of fatty acids is one of the most central metabolic pathways in all forms of l...
Megasynthases are large multienzyme proteins that produce a plethora of important natural compounds ...
SummaryIn yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out...
The yeast fatty acid synthase (FAS) is a barrel-shaped 2.6 MDa complex. Upon barrel-formation, two m...
Two recent papers in Science reported the X-ray structures of the large, organizationally distinct a...
In all organisms, fatty acid synthesis is achieved in variations of a common cyclic reaction pathway...
All steps of fatty acid synthesis in fungi are catalyzed by the fatty acid synthase, which forms a 2...
The homodimeric mammalian fatty acid synthase is one of the most complex cellular multienzymes, in t...
Eukaryotic fatty acid synthases (FASs) are huge multifunctional enzymes that carry out all enzymatic...
On page 1667 of this issue, Stuart Smith and colleagues [1] demonstrate that the animal fatty acid s...
Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesi...
Fatty acids are one of the most abundant lipids in the cell. Cells use them to build biological memb...
The metazoan cytosolic fatty acid synthase (FAS) contains all of the enzymes required for de novo fa...
Modularity is an aspect of a decomposable system with a coordinating authority that acts as a glue w...
Fungal fatty acid synthase (fFAS) is a key paradigm for the evolution of complex multienzymes. Its 4...
The de novo synthesis of fatty acids is one of the most central metabolic pathways in all forms of l...
Megasynthases are large multienzyme proteins that produce a plethora of important natural compounds ...
SummaryIn yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out...
The yeast fatty acid synthase (FAS) is a barrel-shaped 2.6 MDa complex. Upon barrel-formation, two m...
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