Two recent papers in Science reported the X-ray structures of the large, organizationally distinct animal and fungal fatty acid synthases at 5 Å. These new structural insights have unexpected implications for enzyme function for the other “iterative” and “assembly line” megasynthases
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attributi...
Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesi...
SummaryExpression, characterization, and mutagenesis of a series of N-terminal fragments of an anima...
Two recent papers in Science reported the X-ray structures of the large, organizationally distinct a...
In all organisms, fatty acid synthesis is achieved in variations of a common cyclic reaction pathway...
On page 1667 of this issue, Stuart Smith and colleagues [1] demonstrate that the animal fatty acid s...
Fatty acids are one of the most abundant lipids in the cell. Cells use them to build biological memb...
SummaryIn yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out...
The de novo synthesis of fatty acids is one of the most central metabolic pathways in all forms of l...
SummaryFungal fatty acid synthase (fFAS) is a key paradigm for the evolution of complex multienzymes...
While a deep understanding of the fungal and mammalian multi-enzyme type I fatty-acid synthases (FAS...
The homodimeric mammalian fatty acid synthase is one of the most complex cellular multienzymes, in t...
SummaryAnimals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase comple...
Modularity is an aspect of a decomposable system with a coordinating authority that acts as a glue w...
In this thesis, we characterized megasynthases such as fatty acid synthases (FASs) and polyketide sy...
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attributi...
Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesi...
SummaryExpression, characterization, and mutagenesis of a series of N-terminal fragments of an anima...
Two recent papers in Science reported the X-ray structures of the large, organizationally distinct a...
In all organisms, fatty acid synthesis is achieved in variations of a common cyclic reaction pathway...
On page 1667 of this issue, Stuart Smith and colleagues [1] demonstrate that the animal fatty acid s...
Fatty acids are one of the most abundant lipids in the cell. Cells use them to build biological memb...
SummaryIn yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out...
The de novo synthesis of fatty acids is one of the most central metabolic pathways in all forms of l...
SummaryFungal fatty acid synthase (fFAS) is a key paradigm for the evolution of complex multienzymes...
While a deep understanding of the fungal and mammalian multi-enzyme type I fatty-acid synthases (FAS...
The homodimeric mammalian fatty acid synthase is one of the most complex cellular multienzymes, in t...
SummaryAnimals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase comple...
Modularity is an aspect of a decomposable system with a coordinating authority that acts as a glue w...
In this thesis, we characterized megasynthases such as fatty acid synthases (FASs) and polyketide sy...
© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attributi...
Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesi...
SummaryExpression, characterization, and mutagenesis of a series of N-terminal fragments of an anima...