Increased Cardiac Myocyte PDE5 Levels in Human and Murine Pressure Overload Hypertrophy Contribute to Adverse LV Remodeling
- Vandenwijngaert Sara
- Pokreisz Peter
- Hermans Hadewich
- Gillijns Hilde
- Pellens Marijke
- Bax Noortje A. M.
- Coppiello Giulia
- Oosterlinck Wouter
- Balogh Agnes
- Papp Zoltan
- Bouten Carlijn V. C.
- Bartunek Jozef
- D'hooge Jan
- Luttun Aernout
- Verbeken Erik
- Herregods Marie Christine
- Herijgers Paul
- Bloch Kenneth D.
- Janssens Stefan
DOIAbstract
The intracellular second messenger cGMP protects the heart under pathological conditions. We examined expression of phosphodiesterase 5 (PDE5), an enzyme that hydrolyzes cGMP, in human and mouse hearts subjected to sustained left ventricular (LV) pressure overload. We also determined the role of cardiac myocyte-specific PDE5 expression in adverse LV remodeling in mice after transverse aortic constriction (TAC)..Myocardial PDE5 expression is increased in the hearts of humans and mice with chronic pressure overload. Increased cardiac myocyte-specific PDE5 expression is a molecular hallmark in hypertrophic hearts with contractile failure, and represents an important therapeutic target
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