<p>(<b>A</b>) Immunoblot analysis showed increased PDE5 protein expression after chronic pressure overload. Protein levels of GAPDH were measured to control for sample variability. (<b>B</b>) Immunohistochemical staining of PDE5 demonstrated that increased PDE5 expression was present in cardiac myocytes. Colocalization was confirmed in confocal images of double immunofluorescent staining of PDE5 (green) and desmin (red). Scale bars, 20 µm.</p
Background-Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP cata...
Though long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 ...
Though long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 ...
The intracellular second messenger cGMP protects the heart under pathological conditions. We examine...
<p>(<b>A</b>) In cardiac tissue of control subjects, PDE5 expression was limited. In contrast, in AS...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
<div><p>Background</p><p>The intracellular second messenger cGMP protects the heart under pathologic...
BACKGROUND: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background— Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP cat...
Background—Phosphodiesterase type 5 (PDE5) inhibition has been shown to exert profound beneficial ef...
<div><p>Phosphodiesterase-5 (PDE5) is highly expressed in the pulmonary vasculature, but its express...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background-Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP cata...
Though long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 ...
Though long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 ...
The intracellular second messenger cGMP protects the heart under pathological conditions. We examine...
<p>(<b>A</b>) In cardiac tissue of control subjects, PDE5 expression was limited. In contrast, in AS...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
<div><p>Background</p><p>The intracellular second messenger cGMP protects the heart under pathologic...
BACKGROUND: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background— Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP cat...
Background—Phosphodiesterase type 5 (PDE5) inhibition has been shown to exert profound beneficial ef...
<div><p>Phosphodiesterase-5 (PDE5) is highly expressed in the pulmonary vasculature, but its express...
Background: The intracellular second messenger cGMP protects the heart under pathological conditions...
Background-Ventricular expression of phosphodiesterase-5 (PDE5), an enzyme responsible for cGMP cata...
Though long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 ...
Though long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 ...