Adaptation of Madin-Darby canine kidney cells to hypertonic medium: An electron microprobe analysis

Adaptation of Madin-Darby canine kidney cells to hypertonic medium: An electron microprobe analysis. Madin-Darby canine kidney (MDCK) cells of confluent epithelial sheets grown on permeable supports respond to hyperosmotic stress by short- and long-term regulatory volume increase (RVI). Although short-term RVI includes the uptake of inorganic electrolytes, long-term RVI does not and seems therefore to result from accumulation of organic osmolytes