Hypertonic induction of the cell adhesion molecule beta

Hypertonic induction of the cell adhesion molecule pi-integrin in MDCK cells. Am. J. PhysioZ. 273 (CeZZ PhysioZ. 42): C902-C908, 1997.-Cells of many organisms adapt to os-motic stress by accumulating compatible organic osmolytes. In Madin-Darby canine kidney (MDCK) cells, a renal epithe-lial cell line widely used as a culture model for the study of osmotic regulation in mammals, extracellular hypertonicity induces genes responsible for the accumulation of organic osmolytes. We have recently cloned from these cells a partial cDNA corresponding to a member of the transmembrane 4 superfamily (tetraspan) family, CD9 antigen, and demon-strated its induction by hypertonicity [D. Sheikh-Hamad, J