How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. (2010) now use single-cell microscopy to demonstrate that alternative posttranslational modifications allow the tumor suppressor p53 to differentiate between benign breaks in DNA during the cell cycle and deleterious damage caused by mutagens
Summaryp53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest,...
A cell has to react to a multitude of different extrinsic and intrinsic stress signals on a daily ba...
The tumor suppressor p53 regulates various stress responses via increasing its cellular levels. The ...
How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. ...
The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apoptosis and...
SummaryThe tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apopto...
Background: The p53 pathway is differentially activated in response to distinct DNA damage, leading ...
A hallmark of tumour cells is evident in the control of the G1 to S phase transition. In normal cell...
The p53 tumour suppressor is the most frequently mutated gene in human cancer. This transcription fa...
DNA damage triggers a checkpoint response that involves a myriad of cellular responses including cel...
BACKGROUND The tumor suppressor protein p53 is activated by cellular stress. DNA double strand br...
Summary: To enable reliable cell fate decisions, mammalian cells need to adjust their responses to d...
P53 is known as the most critical tumor suppressor and is often referred to as the guardian of our g...
p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senesc...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
Summaryp53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest,...
A cell has to react to a multitude of different extrinsic and intrinsic stress signals on a daily ba...
The tumor suppressor p53 regulates various stress responses via increasing its cellular levels. The ...
How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. ...
The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apoptosis and...
SummaryThe tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apopto...
Background: The p53 pathway is differentially activated in response to distinct DNA damage, leading ...
A hallmark of tumour cells is evident in the control of the G1 to S phase transition. In normal cell...
The p53 tumour suppressor is the most frequently mutated gene in human cancer. This transcription fa...
DNA damage triggers a checkpoint response that involves a myriad of cellular responses including cel...
BACKGROUND The tumor suppressor protein p53 is activated by cellular stress. DNA double strand br...
Summary: To enable reliable cell fate decisions, mammalian cells need to adjust their responses to d...
P53 is known as the most critical tumor suppressor and is often referred to as the guardian of our g...
p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senesc...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
Summaryp53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest,...
A cell has to react to a multitude of different extrinsic and intrinsic stress signals on a daily ba...
The tumor suppressor p53 regulates various stress responses via increasing its cellular levels. The ...
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