How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. (2010) now use single-cell microscopy to demonstrate that alternative posttranslational modifications allow the tumor suppressor p53 to differentiate between benign breaks in DNA during the cell cycle and deleterious damage caused by mutagens
Abstractp53 is a tumor suppressor and the p53 dynamics displays stimulus dependent patterns. Recent ...
The tumor suppressor p53 is commonly referred to as the guardian of the genome due to its ability ...
The tumor suppressor p53 protein shows various dynamic responses depending on the types and extent o...
How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. ...
SummaryThe tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apopto...
BACKGROUND: The tumor suppressor protein p53 is activated by cellular stress. DNA double strand brea...
BACKGROUND The tumor suppressor protein p53 is activated by cellular stress. DNA double strand br...
The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apoptosis and...
Summaryp53 induces cell death upon DNA damage, but this may not confer all of its tumor suppressor a...
Background: The p53 pathway is differentially activated in response to distinct DNA damage, leading ...
A cell has to react to a multitude of different extrinsic and intrinsic stress signals on a daily ba...
DNA damage triggers a checkpoint response that involves a myriad of cellular responses including cel...
The tumor suppressor p53 protein shows various dynamic responses depending on the types and extent o...
Hallmark to most cancers is the mutation or complete loss of function of the tumor-suppressor gene p...
Summaryp53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest,...
Abstractp53 is a tumor suppressor and the p53 dynamics displays stimulus dependent patterns. Recent ...
The tumor suppressor p53 is commonly referred to as the guardian of the genome due to its ability ...
The tumor suppressor p53 protein shows various dynamic responses depending on the types and extent o...
How do regulatory switches achieve high sensitivity within the noisy cellular milieu? Loewer et al. ...
SummaryThe tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apopto...
BACKGROUND: The tumor suppressor protein p53 is activated by cellular stress. DNA double strand brea...
BACKGROUND The tumor suppressor protein p53 is activated by cellular stress. DNA double strand br...
The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apoptosis and...
Summaryp53 induces cell death upon DNA damage, but this may not confer all of its tumor suppressor a...
Background: The p53 pathway is differentially activated in response to distinct DNA damage, leading ...
A cell has to react to a multitude of different extrinsic and intrinsic stress signals on a daily ba...
DNA damage triggers a checkpoint response that involves a myriad of cellular responses including cel...
The tumor suppressor p53 protein shows various dynamic responses depending on the types and extent o...
Hallmark to most cancers is the mutation or complete loss of function of the tumor-suppressor gene p...
Summaryp53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest,...
Abstractp53 is a tumor suppressor and the p53 dynamics displays stimulus dependent patterns. Recent ...
The tumor suppressor p53 is commonly referred to as the guardian of the genome due to its ability ...
The tumor suppressor p53 protein shows various dynamic responses depending on the types and extent o...
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