The role of circadian clock genes in tumors

Han-Xue LiDepartment of Preventive Dentistry, Stomatological Hospital of Chongqing Medical University, Chongqing 400015, People’s Republic of ChinaAbstract: Circadian rhythms are generated via variations in the expression of clock genes that are organized into a complex transcriptional–translational autoregulatory network and regulate the diverse physiological and behavioral activities that are required to adapt to periodic environmental changes. Aberrant clock gene expression is associated with a heightened risk of diseases that affect all aspects of human health, including cancers. Within the past several years, a number of studies have indicated that clock genes contribute to carcinogenesis by altering the expression of clock-controlled and tumor-related genes downstream of many cellular pathways. This review comprehensively summarizes how clock genes affect the development of tumors and their prognosis. In addition, the review provides a full description of the current state of oral cancer research that aims to optimize cancer diagnosis and treatment modalities.Keywords: circadian rhythms, clock genes, oral squamous cell carcinoma, carcinogenesis, oral cance