ClnR acts as a conditional repressor and inducer of <i>clnRAB</i> expression.

Cultures of 630Δerm, clnR (MC885), clnR Tn::clnRAB (MC950), clnAB (MC935), and clnAB Tn::clnRAB (MC953) were grown in BHIS alone or BHIS with 2 μg/ml LL-37. RNA samples were collected and processed for qRT-PCR analysis as described in Methods. Graphs show the mean mRNA expression levels of A) clnR and B) clnA relative to expression in strain 630Δerm in BHIS alone. Error bars represent the standard error of the mean from at least three independent experiments. Data were analyzed by two-way ANOVA and Tukey’s multiple comparisons test, with comparisons indicated by brackets. * indicates p p ≤ 0.0001.